PROFESSIONAL EXPERIENCE
2000-2009 Research Biologist, Department of In Vivo Sciences, Merck Frosst Canada.
1996-2000 Staff Biologist, Department of Pharmacology, Merck Frosst Canada.
1994-1996 Biologist, Department of Pharmacology, Merck Frosst Canada.
1988-1994 Research Fellow, Meakins-Christie Laboratories, McGill University.
1982-1985 Pediatrician, Third People’s Hospital of Chongqing, China.
EDUCATION
1986-1988 M.Sc. (Physiology), McGill University, Montreal, Canada
1978-1982 M.D. (Medicine), Chongqing Medical University, China
2000-2009 Performed in vivo and in vitro studies to support drug development in diabetes and obesity
1988-2000 Performed in vivo and in vitro studies to support development of Arcoxia, Vioxx and other drug candidates in inflammation, asthma and COPD
1986-1988 Performed exploratory research to examine the effect of hypoxia and hyperoxia on the lung of the chick embryo and newborn rats.
MANAGERIAL SKILLS
· Developed, designed and organized study protocols using diet-induced obese (DIO), db/db, ob/ob, high sucrose diet fed mice and Zucker obese, Zucker obese diabetic rats for experiments to support diabetes and obesity drug targets.
· Coordinated research activities among chemists, biochemists and biologists. Responsible for data analysis, presentation and writing reports.
· Presented data in Friday afternoon scientific reviews, departmental meetings and lab meetings
· Presented data in external scientific meetings (ATS, FASEB and World Congress of Pharmacology)
· Supervised ten Merck co-op students (from UBC, McMaster and Sherbrooke University) and technicians. Provided input to students to prepare for seminar presentations.
TECHNICAL SKILLS
· Performed oGTT (oral glucose tolerance test); iTT (insulin tolerance test); qMNR (quantitative nuclear magnetic resonance) measuring body fat and lean mass; food intake, activity and metabolic rate measurement using CLAMs (Complete Laboratory Automated Monitoring System, Columbus Instrument); monitored body weight changes and blood glucoses by tail bleeds in chronic studies
· Performed stomach blood flow measurement using laser Doppler flowmeter (LPD, Perimed AB) Instruments)
· Performed lung function measurement using FlexiVent (SCIREQ) and PenH (Buxco) systems in rats, mice and guinea pigs
· Performed surgery on rodents: tracheotomy, bile duct and jugular vein canulation; subcutaneous mini-pump implantation; compound dosing by oral, intraperitoneal, intramuscular, subcutaneous and tail vein injection routes
· Performed bronchoalveolar lavage (BAL) and cytological analysis of BAL cells using cytospin,
· In vitro assays: performed RIA, ELISAs of insulin, leptin, cytokines and Cartlilage Oligomeric Matrix Protein, EIA of free fatty acid and ketone bodies, and multiplex assays using MesoScale (MSD) platform, cell culture, using automated system for screening test
· Performed high-performance liquid chromatography (HPLC) analysis of compound levels in plasma and tissues to support pharmacokinetics studies.
COMPUTER SKILLS
Working knowledge of Windows XP, Windows 98, Windows NT workstation. MS Word, MS Excel, MS Powerpoint, GraphPad-Prism, SigmaPlot, Immunofit (EIA, RIA), Internet, Outlook and web site creation.
Languages: English and Chinese. Citizen: Canadian Association: American Thoracic Society (ATS).
M.Sc. THESIS:
The lung and oxygen development in chicken embryo and rats. M.Sc. thesis, McGill University, Canada. (1988).
PAPERS:
1. Y Mamane, CC Chan, G Lavallee, N Morin, LJ Xu, JQ Huang, R Gordon, W homas, J Lamb, EE Schadt, BP Kennedy & JA Mancini. Deletion of the C3a anaphylatoxin receptor results in increased insulin sensitization through modulation of adipose tissue macrophage function. Diabetes , 58(7), 2009
2. A-M Pulichino, I-M Wang, A Caron, J Mortime, A Auger, Y Boie, J A Elias, A Katono, LJ Xu, J Menetski and CE Sayegh. Identifcation of transforming growth factor b1-driven genetic programs regulating lung fibrosis, Am J Respir Cell Mol Biol. 2008 Apr 10.
3. C Dufresne, P Roy, Z Wang, E Asante-Appiah, W Cromlish, Y Boie, F Forghani S Desmarais, Q Wang, K Skorey, , D Waddleton, C Ramachandran, BP. Kennedy, LJ Xu, R Gordon, CC Chan, and Y Leblanc, The development of potent non-peptidic PTP-1B inhibitors, Bioorg Med Chem Lett 2004, 14(4), 1039-1042.
4. WC Black, C Brideau, C-C Chan, S Charleson, W Cromlish, R Gordon, EL Crimm, G Hughes, S Leger, C-S Li, D Riendeau, M Therien, Z Wang, LJ Xu and P Prasit, 3. 4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-with aqueous solubility, Bioorg Med Chem Lett 2003, 13, 1195-1198.
5. SS Nag, LJ Xu, Q Hamid and PM Renzi. The effect of IL-5 on airway physiology and inflammation in rats. J. Allergy Clin. Immuno., 111(3):558-66, 2003 Mar.
8. D Riendeau MD Percival, C Brideau, S Charleson, D Dube, D Ethier, JP Falgueyret, R Friesen, R Gordon, G Greig, J Guay, J Mancini, M Quellet, E Wong, LJ Xu, S Boyce, D Visco, Y Girard, P Prasit, Zamboni, M Gresser, AW Ford-Hutchinson, RN Young and CC Chan, Etoricoxib (MK-0663): Preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2, J Pharmacol Exp Ther, 296 (2):558-566, Feb., 2001.
9. LJ. Xu, R. Olivenstein, J.G. Martin and W.S. Powell, Effects of inhaled budesonide on allergen-induced airway narrowing, airway inflammation and leukotriene synthesis in rats. J. Appl. Physiol., 2000; 89:1852-1858.
10. Yang X.X, Ho G, Xu L.J, Powell WS, Martin JG, The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. Pulm Pharmacol Ther 1999; 12(5):325-9.
11. Lau CK, Brideau C, Chan CC, Charleson S, Cromlish WA, Ethier D, Gauthier JY, Gordon R, Guay J, Kargman S, Li CS, Prasit P, Riendeau D, Therien M, Visco DM, Xu LJ . Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors. , Bioorg Med Chem Lett 1999 Nov 15;9(22):3187-92.
12. P. Renzi, LJ. Xu, X.X. Yang, W.S. Powell and J.G. Martin, IL-2 enhances allergic airway responses in rats by increased inflammation but not through increased synthesis of cysteinyl leukotrienes, J. Allergy Clin. Immunol, 104 (1):145-152, Jul, 1999.
13. Li CS, Black WC, Brideau C, Chan CC, Charleson S, Cromlish WA, Claveau D, Gauthier JY, Gordon R, Greig G, Grimm E, Guay J, Lau CK, Riendeau D, Therien M, Visco DM, Wong E, Xu LJ Prasit P. A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 1999 Nov 15;9(22):3181-6
14. Leblanc Y, Roy P, Boyce S, Brideau C, Chan CC, Charleson S, Gordon R, Grimm E, Guay J, Leger S, Li CS, Riendeau D, Visco D, Wang Z, Webb J, Xu LJ, Prasit P, SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor. Bioorg Med Chem Lett 1999 Aug 2;9(15):2207-12
15. C.C. Chan, S. Boyce, C. Brideau, S. Charleson, W. Cromlish, D. Ethier, J. Evans, A.W. Ford-Hutchinson, M.J. Forrest, J Y. Gauthier, R. Gordon, M. Gresser, J. Guay, S. Kargman, B. Kennedy, Y. Leblanc, S. Leger, J. Mancini, G P. O'Neill, M. Ouellet, D. Patrick, M. D. Percival, H. Perrier, P. Prasit, I. Rodger, P. Tagari, M. Therien, P. Vickers, D. Visco, Z. Wang, J. Webb, E. Wong, L-J. Xu, R. N. Young, R. Zamboni and D. Riendeau, [Vioxx, MK-0966;4-(4'-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles. J Pharmacol Exp Ther 1999 Aug 1;290(2):551-560.
16. P. Prasit, Z. Wang, C. Brideau, C.C. Chan, S. Charleson, W. Cromlish, D. Ethier, J.F. Evans, A.W Ford-Hutchinson, JY Gauthier, R. Gordon, J. Guay, M. gresser, S. Kargman, B. Kennedy, Y. Leblanc, S. Leger, J.A. Mancini, G. O’Neill, M. Ouellet, H. Perrier, D. Riendeau, I. Rodger, P. Tagari, M. Therien, P. Vickers, E. Wong, L.J. Xu, R.N. Young and R. Zamboni. The discovery of rofecoxib, [MK966, VIOXX, 4-(4-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor. Bioorganic and Medicinl Chemistry Letters, Vol. 9, pp. 1773-1778, 1999
17. T. Du, J.G. Martin, L J. Xu, W.S. Powell and P.M. Renzi, IL-3 dose not affect the allergic airway responses and leukotriene production after allergen challenge in rats. Eur Respir J 13(5): 970-5, May, 1999.
18. 17. W. C. Black, C. Brideau, C.C Chan, S. Charleson, N Chauret, D.Denis, R. Gordon, G. Greig, J Guay, G. Hughers, P Jolicoeur, Y Leblanc, D. Nicoll-Griffith, N Ouimet, D. Riendeau, D. Visco, Z.Wang, LJ. Xu, and P. Prasit. 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors, J. Medicinal Chemistry, Vol. 42, No. 7, pp1274-1281, 1999.
19. X.X. Yang, W.S. Powell, L J. Xu and J.G.martin. Strain dependence of the airway response to dry gas hyperpnea challenge in the rats. J. Appl. Physiol. 86(1):152-158, Jan. 1999
20. R.W. Friesen, C. Brideau, C.C Chan, S. Charleson, D.Denis D. Dube, D. Ethier, R. Fortin, J.Y. Gauthier, Y. Girard, R. Gordon, G.M. greig, D. Riendeau, C. Savoie, Z. Eang, E. wong, D. Visco, LJ. Xu and R.N. Young. 2-pyridinyl-3-(4-methylsulfonyl) phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors. Bioorganic and Medicinl Chemistry Letters, Vol. 8, No. 22, pp. 2777-2782, 1998.
21. R. Olivesteinin, T. Du, L J. Xu and J.G. Martin, Microvascular leakage in the airway wall and lumen during allergen induced early and late response in rats. Pulmonary pharmacology & Therapeutics 10, 223-230, Aug. 1997.
22. D. Riendeau, M.D. Percival, S. Boyce, C. Brideau, S. Charleson, W. Cromlish, D. Ethier, J. Evans, JP. Falgueyret, AW Ford-Hutchinson, R. Gordon, G. Greig, M. Gresser, J. Guay, S. Kargman, S. Leger, J.A. Mancini, G. O’Neill, M. Ouellet, I.W. Rodger, M. Therien, Z. Wang, J.K. Wenn, E. Wong, LJ. Xu, R.N. Young, R. Zamboni, P. Prasit and C.C. Chan. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. British Journal of Pharmacology, 121, pp. 105-117, 1997.
23. P. Roy, Y. Leblanc, R.G. Ball, C. Brideau, C.C. Chan, W. Cromlish, D. Ethier, J.U. Gauthier, R. Gordon, G. Greig, J. Guay, S. Kargman, C.K. Lau, G. O’Neill, J. Silva, M. Therien, C. van Staden, E. Wong, LJ. Xu, and P. Prasit . A new series of selective COX-2 inhibitors:5,6-diarylthiazolo[3,2-b][1,2,4] triazoles. Bioorganic & Medicinal Chemistry Letters, Vol.7, No. 1, pp. 57-62, 1997.
24. M Therien, C. Brideau, C.C. Chan, W. Cromlish, J.U. Gauthier, R. Gordon, S. Kargman, CK Lau, Y. Leblanc, CS Li, G. O’Neill, D. Riendeau, P Roy, Z Wang, LJ Xu and P. Prasit. Synthese and biological evalustion of 5,6-Diarylimidazo [2.1-b] thiazole as selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry Letters, Vol.7, No. 1, pp. 47-52, 1997.
25. Y.L. Jia, LJ. Xu, D. J. Turner and J.G. Martin. Endogenous nitric oxide contributes to strain-related differences in airway responsiveness in rats. J. Appl. Physiol. 80(2): 404-410, Feb. 1996.
26. S. Laberge, L. Wu, R. Olivenstein, L J. Xu, P. M. Renzi and J.G. martin. Depletion of CD8+ T-cells enhances pulmonary inflammation but not airway responsiveness after antigen challenge in rats. Allergy and Clinical Immunology. Vol. 98 No. 3, pp. 617-627, Sept. 1996.
27. C. C. Chan and L J. Xu, Development of novel anti-inflammatory drugs. Bio/Pharma Quarterly (Chinese. Vol.2, No.1, p12-14, Mar. 1996.
28. W.C. Black, C. Bayly, M. Belley, C.C. Chan, S. Charleson, D.Denis, J.Y. Gauther, R. Gordon, D. Guay, S. Kargman, C.K. Lau, Y. Leblanc, J. Mancini, M. Ouellet, D. Percival, P. Roy, K. Skorey, P. Tagari, P. Vickers, E. Wong, LJ. Xu, and P. Prasit. From indomethacin to a selective COX-2 inhibitor: development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors. Bioorganic and Medicinl Chemistry Letters, Vol. 6, No. 6, pp. 725-730, 1996.
29. Y. Leblanc, W.C. Black, C.C. Chan, S. Charleson, D. Denis, J.Y. Gauther, E.L. Grimm, R. Gordon, D. Guay, P. Hamel, S. Kargman, C.K. Lau, J. Mancini, M. Ouellet, D. Percival, P. Roy, K. Skorey, P. Tagari, P. Vickers, E. Wong, LJ. Xu, and P. Prasit. Synthese and biological evalustion of both enantiomers of L-761, 000 as inhibitors of cyclooxygenase 1 and 2. Bioorganic and Medicinl Chemistry Letters, Vol. 6, No.6, pp. 731-736, 1996.
30. R.W. Friesen, D. Dube, R.Fortin, R. Frenette, S Prescott, W Cromlish, G.M. Greig, S. Kargman, E. Wong, C.C. Chan, R. Gordon, L J. Xu and D. Riendeau. Novel 1,2-diarylcyclobutenes: selective and orally active COX-2 inhibitors. Bioorganic and Medicinl Chemistry Letters, Vol. 6, No. 22, pp. 2677-2682, 1996.
31. JY Gauthier, Y Leblanc. WC Black, CC Chan, WA Cromlish, R Gordon, BP Kennedey, CK Lau, S Lerge, ZY Wang, D Ethier, J Guay, J Mancini, D Riendeau, P Tagari, P Vickers, E Wong, LJ Xu & P Prasit Synthesis and biological evaluation of 2, 3-diarylthiophenes as selective cox-2 inhibitors. Part II: replacing the heterocycle. Bioorganic and Medicinl Chemistry Letters, Vol. 6, No. 1, pp. 87-92, 1996.
32. W.S. Powell, L J. Xu and J.G.Martin. Effects of dexamethasone on leukotriene synthesis and airway responses to antigen and leukotriene D4 in rats. Am. J. Respir. Crit. Care Med. 151:1143-50, 1995.
33. A Watanabe, P. Rossi, P.M. Renzi, L J. Xu, R.D. Guttmann and J.G. Martin. Adoptive transfer of allergic airway responses with senstized lymphocytes in the BN rast. Am. J. Respir. Crit. Care Med. 152:64-70, Jul. 1995.
34. Y.L. Jia, LJ. Xu, S. Heisler and J.G.martin. Airways of a hyperresponsive rat strain show decreased relaxant responses to sodium nitroprusside. Am. J. Physio. 269 (lung cell Mol. Physiol. 13).L85-L91, 1995.
35. Watanabe, H. Mishima, P.M. Renzi, LJ. Xu, O. Hamid and J.G. Martin. Transfer of allergic airway responses with antigen-primed CD4+ but not CD*+ T cell in brown Norway rats. J. Clin. Invest. 96: 1303-1310, Sept. 1995.
36. W.G. Yu, LJ. Xu, J.G.Martin and W.S. Powell. Cellular infiltration and eicosandoid synthesis in Brown Norway rat lung after allergen challenge. Am. J. Respir. Cell Mol biol. 13 (4): 477-486, Oct. 1995.
37. Waserman S, Xu LJ, Olivenstein R, Renzi PM, Martin JG Association between late allergic bronchoconstriction in the rat and allergen-stimulated lymphocyte proliferation in vitro. Am J Respir Crit Care Med. 151(2 Pt 1):470-4. Feb. 1995.
38. L J. Xu, R.J. Danurand, M. Lei and D.H. Eidelman. Airway hyperresponsiveness in cigarette smoke-exposed rats. Lung, 171(2): 5-107, 1993.
39. P. Rossi, LJ. Xu, N.S. Wang and J.G.Martin. Allergen-induced airway responses in rats pretreated with Sephadex. Agents Actions 40(3-4): 141-149, Nov. 1993.
40. C.G. Wang, T.Du, L J. Xu and J.G.Martin. Increase in airway responses and smooth muscle may be mediated by leukotriene D4 (LTD4) in sensitized BN rats. Am. Rev. Respir. Dis., 148(2): 413-417, Aug. 1993.
41. J.G. Martin, L J. Xu, M.Y. Toh, R. Olivenstein and W.S. Powell. Leukotriene metalolites in bile of sensitized rats following tracheal instillation of antigen. Am. Rev. Respir. Dis., 147(1): 104-110, Jan. 1993.
42. L J. Xu, S. Sapienza, T.Du, S. Waserman and J.G. Martin. A comparsion of upper airway and lower airway responses of two sensitized rat strains to inhaled antigen. J. Appl. Physiol. 73(4): 1608-1613, 1992.
43. R.J. Danurand, L J. Xu ,J.G.Martin and D.H. Eidelman. Airway-paraenchymal interdependence and bronchial responsiveness in two highly inbred rat strains. J. Appl. Physiol. 74(2): 538-544, Feb. 1992.
44. S. Waserman, R. Olivesteinin, P. Renzi, L. Xu and J.G. Martin. The relationship between late asthmatic response and antigen specific immunoglobulin. J. All. Clin. Immun., 90(4 pt 1): 661-9, Oct 1992.
45. T.Du, L J. Xu, M. Lei, N.S. Wang, D.H. Eidelman, H. Ghezzo and J.G. Martin. Morphometric changes during the early airway response to allergen challenge in the rat. Am. Rev. Respir. Dis., 146: 1037-1041, 1992.
46. L J. Xu, D.H. Eidelamn, J.H.T. Bates and J.G. Martin. Late response of the upper airway of the rat to inhaled antigen, J. Appl. Physiol. 69(4): 1360-1365, 1990.
47. J.P. Mortola, LJ. Xu and A-M Lauzon. Body growth, lung and heart weight, and DNA content in newborn rats exposed to different levels of chronic hypoxia. Can. J. Physiol. Pharmacol. 1990.
48. LJ. Xu and J.P. Mortola, Effects of hypoxia and hyperoxia on lung of the chick embryo, Can. J. Physiol. Pharmacol. 67, 515-519, 1989.
49. LJ. Xu and J.P. Mortola, Development of chick embryo: effects of egg mass, Resp. Physic. 74, 177-186, 1988.
BIBLIOGRAPHY: (ABSTRACT AND PRESENTATION)
1. CC Chan, LJ Xu, EE Schadt, J Lamb, BP kennedy and JA Mancini, C3aR1 -/- are less sensitive to diet induce obesity and have a decreased insulin excursion on high fat diet. Keystone meeting on Nuclear receptors and metabolic syndrome, Mar, 2007
2. QP Wang, D`Waddieton, JP Kirwood, L Xu, E Kwok, Identification of the phospholyrosine proteome from the liver of pervanadate treated mice. 55nd ASMS Conference, 2004
3. LJ Xu, IW. Rodger and CC Chan , Systemic and pulmonary anti-inflammatory effects of PDE4 inhibitors in rats. 99th ATS, 2003.
4. C. Savoie, LJ Xu, A. Robichaud, C. Chan, J. Mancini, Z.Huang, P. Hamel, R Frenette and T. R. Jones. Pharmacological Modulation of LPS -Induced Lung Inflammation in Rats. 99th ATS, 2003.
5. Y Boie, J Mortimer, L Xu, CC Chan and B Kennedy, Microarray analysis of Protein Tyrosine Phosphatase-1B inhibition in a diet-induced obesity mouse model. For EMBL/EMBO Symposium at Heidelberg, 2002.
6. V Patel, LJ Xu, Y Boie, P Payette, J Mortimer, A English, CC Chan and BP. Kennedy Pharmacological and molecular characterization of the diet-induced obese mouse, 45th CFBS, Montreal, June, 2002
7. Xu, L.J., Gordon, R., Charette, L. and Chan, C. Chronic and acute effects of metformin in diet-induced obese mice. For presentation at: Pharmacology 14th World Congress, San Francisco, California, 07/07/2002 - 07/12/2002.
8. M Chevallet, A Kamassah, LJ Xu, CC Chan, C Ramachandran and A Ducret, Serum protein profiling by two-dimensional fluorescence differential gel electrophoresis (2D-DIGE), International meeting on Proteome analysis in Münich, Germany, September 15-19, 2001.
9. LJ Xu, R Gordon, P Payette, S Solyom, B Kennedy and CC Chan. Characterization of A Model of Insulin Resistance: diet-induced Obese Mice. Pharmacology Vancouver 2001 for presentation,
10. L. J. Xu, A. Thilainadrajah and C.C. Chan, Effects of synthetic prostanoids on 5-HT induced bronoconstriction in rats. Am. J. Respir. Crit. Care Med. Vol., No., pp. A874, 1999.
11. L. J. Xu, P. Masson, I.W. Roger and C.C. Chan, Airway hyperreactivity in carrageenan treated rats. Am. J. Respir. Crit. Care Med. Vol. 155, No. 4, pp. A160, 1997.
12. S. S. Nag, L. J. Xu, S. Seguin, Q. Hamid, J.G. Martin and P.M. Renzi. The effect of interleukin-5 (IL-5) on airway physiology and inflammation after antigen challenge in Brown Norway (BN) rats. Am. J. Respir. Crit. Care Med. Vol. 155, No. 4, pp. A161, 1997.
13. P. Renzi, L. J. Xu, X.X. Yang W.S. Powell and J.G. Martin. Mechanism by which stimulation of cellular immunity may enhance the physiological changes described in asthma. Meakin-Christie 25th anniversary reunion, scientific session. Montreal, May 23-24, 1997.
14. Y.L. Jia, L. J. Xu and J.G. Martin. Endogenous nitric oxide contributes to strain-related differences in airway responsiveness in rats. Am. J. Respir. Crit. Care Med. Vol.151, No.4, pp. A127, 1995.
15. L. J. Xu, R. Olivenstein, J.G.Martin and W.S. Powell, Effects of inhaled budesonide on allergen-induced airway narrowing, airway inflammation and leukotriene synthesis in rats. Am. J. Respir. Crit. Care Med. Vol.151, No.4 , pp. A223, 1995.
16. P.M. Renzi, L.J. Xu, A. Watanabe, S. Seguin, Q. Hamid and JG. Martin, The effects of interleukin-5 (IL-5) on cholinergic airway responsiveness and lung inflammation in sensitized Brown Norway (BN) rats. AmJ. Respir Cri. CareMed. Vol.151, No.4, p A827, 1995
17. Watanabe, P. Rossi, L. J. Xu, P.M. Renzi and J.G. Martin. Adptive transfer of T-lymphocytes induces hyperresponsiveness to methacholine after allergic challenge in Brown Norway (BN) rast. Am. J. Respir. Crit. Care Med. Vol.149, No.4, pp. A334, April, 1994.
18. P. Rossi, A. Watanabe, L. J. Xu, P.M. Renzi, R.D. Guttmann and J.G. Martin. In vivo adptive transfer of allergic airway responses with senstized lymphocytes in the BN rast. Am. J. Respir. Crit. Care Med. Vol.149, No.4, pp. A335, April 1994.
19. R. Olivesteinin, P.M. Renzi, L. J. Xu and J.G. Martin, Effects of W3/25 monoclonal antibody on plmonary inflammation and the late airway response in Brown-Norway rats. Am. Rev. Respir. Dis, Vol 149, A528, April, 1994.
20. L. J. Xu, J.G.Martin, X.X. Yang and W.S. Powell, Multiantigen challenge-induced a selective increase in airway responsiveness to leukotriene E4 in Brown Norway (BN) rats. Am. Rev. Respir. Dis, Vol 149, A757, April, 1994
21. J.G. Martin, G.Ho, L.J. Xu, X.X. Yang and W.S. Powell, The effect of -adrenergic agonist on hyperpnea-induced bronchoconstriction(HIB) on biliary leukotrienes (LTs) in guinea pig. Eur. Respir. J. Vol 7, supplement18, pp.236s, Oct. 1994.
22. W.S. Powell, L.J. Xu and J.G.martin. Effects of dexamethasone on leukotriene synthesis and airway responses to antigen and leukotriene D4 in rats. Am. Rev. Respir. Dis, vol 147, No. 4, pp A445, April, 1993.
23. W.G. Yu, L. J. Xu and J.G.Martin and W.S. Powell. Eicosanoid synthesis and cellular infiltration in Brown-Norway rat lung after allergen challenge. Am. Rev. Respir. Dis, vol 147, No. 4, pp A661, April, 1993.
24. X.X. Yang, W.S. Powell, L. J. Xu and J.G.martin. The role of peptide-leukotriene in hyperpnea-induced bronchoconstriction in the guinea pig. Am. Rev. Respir. Dis, vol 147, No. 4, pp A663, April, 1993.
25. L. J. Xu, P.M. Renzi, W.S. Powell and J.G. Martin. The effects of interleukin-2 on airway eosinophilia and biliary peptido-leukotrienes after allergen challenge rats. Am. Rev. Respir. Dis,Vol. 147, No. 4, pp A1011, April, 1993.
26. Du, J.G. Martin, L. J. Xu and P.M. Renzi. The effects of interleukin-3(IL-3) on airway responses and lung inflammation in allergen challenged Brown-Norway (BN) rats, Am. Rev. Respir. Dis,Vol. 147, No. 4, pp A1012, April, 1993.
27. W.G. Yu, L. J. Xu and W.S. Powell. Increase leukotriene synthesis by lung cells after antigen challenge, Am. Rev. Respir. Dis,Vol. 145, No. 4, pp A287, April, 1992.
28. L. J. Xu, J.G.martin and W.S. Powell, The effects of dexamethasone on biliary peptido-leukotrienes after antigen challenge in rats. Am. Rev. Respir. Dis,Vol. 145, No. 4, pp A288, April, 1992.
29. CG. Wang, T.Du, L.J. Xu and JG.Martin. Leukotriene D4 mediates increase in airway responsiveness but not increase in airway smooth muscle (ASM) following multiple exposures to ovalumin (OA) in sensitized rats. Am.Rev.Respir.Dis,Vol. 145, No 4, pA288, April, 1992.
30. S. Waserman, L. J. Xu, R. Olivesteinin and J.G. Martin. The association between late allergic bronchoconstriction in the rat and allergen-stimulated lymphocyte proliferation in vitro, Am. Rev. Respir. Dis,Vol. 145, No. 4, pp A490, April, 1992.
31. P. Rossi, L. J. Xu and J.G.Martin. The effect of sephadex on allergen induced airway responses in the rat. Am. Rev. Respir. Dis,Vol. 145, No. 4, pp A490, April, 1992.
32. L. J. Xu, M.Y. Toh, R. Olivenstein, J.G. Martin and W.S. Powell. Leukotriene metalolites in bile of sensitised rats following tracheal instillation of antigen. Am. Rev. Respir. Dis., Vol. 143, No. 4, pp A637, April 1991.
33. T. Du, L. J. Xu, M. Lei, N.S. Wang and J.G. Martin. The mechanism of airway narrowing during the early response (ER) to allergen challenge in the rat. Am. Rev. Respir. Dis., Vol. 143, No. 4, pp A351, April, 1991
34. D.H. Eidelman, R.S. Sake, W.A. Zin, P.H.N. Saldiva, M.A. Martins, L. J. Xu and J. Millc-Emili, Airway and tissue response to inhaled methacholine, Am. Rev. Respir. Dis., Vol. 143, No. 4, pp A353, April 1991.
35. L. J. Xu, S. Sapienza, T.Du, S. Waserman and J.G. Martin. A comparsion of upper airway and pulmonary responsiveness of hihly inbred rats inhaled antigen. Am. Rev. Respir. Dis., Vol. 143, No. 4, pp A417, April, 1991.
36. R. Olivesteinin, T. Du, L. J. Xu, N.S. Wang and J.G. Martin, Airway microvascular permeability during allergen induced early and late response in rats. Am. Rev. Respir. Dis., Vol. 143, No. 4, pp A419, April 1991.
37. R.J. Danurand, L.J. Xu ,JG.Martin and D.H. Eidelman. Effect of volume on Methacholine (MCh) Dose-Response Curves (DRCS) in two inbred rat strains. Am. Rev. Respir. Dis., 1990.
38. L.J. Xu, R.J. Danurand, M. Lei and D.H. Eidelman. Airway hyperresponsiveness in cigarette smoke-exposed rats, for APS/FASEB meeting, Washington D.C., April1-5, 1990.
39. L. Xu, DH. Eidelamn, JHT. Bates and JG. Martin. Upper airway late responses of sensitized rats to antigen provacation, for APS mettinh, Rochester, Oct. 14-19, 1989.
40. J.P. Mortola and L. Xu, Development of chick embryo: effects of egg mass, for APS Meeting, Montreal, Oct. 9-13, 1988.
